Protein DJ-1 (63-89) Heavy
Ref. 3D-CRB1300699
| 25nMol | 452,00 € |
Informação sobre produto
- H-EGPYDVVVL^PGGNLGAQNLSESAAVK-OHEGPYDVVV-[U-13C6,15N-Leu]-PGGNLGAQNLSESAAVK-acidH-Glu-Gly-Pro-Tyr-Asp-Val-Val-Val-[U-13C6,15N-Leu] -Pro-Gly-Gly-Asn-Leu-Gly-Ala-Gln- Asn-Leu-Ser-Glu-Ser-Ala-Ala-Val-Lys-OH
DJ-1 play various roles in cellular homeostasis such as protein quality control, mitochondrial function, protecting cells from oxidative injury, and regulating gene transcription.DJ-1 can activate the extracellular signal-regulated kinase (ERK1/2) pathway to mediate dopamine (DA) homeostasis and mutations in PARK7, the gene which encodes DJ-1 can cause autosomal-recessive early-onset parkinsonism. Activation of the ERK pathway also plays a role in oncogenesis by encouraging inappropriate cell proliferation and survival. Overexpression and secretion of DJ-1 is associated with a vast number of tumour types. DJ-1 can also activate the phosphatidylinositol-3-kinase PI3k/Akt pathway to mediate stress-induced cellular responses such as cell survival and proliferation. The role of DJ-1 in this pathway is linked to multiple disease states such as: Alzheimer disease- Parkinson disease- clear cell renal cell carcinoma (ccRCC)- renal tubular epithelial-mesenchymal transition (EMT), and metastasis of gastric carcinoma.DJ-1 can inhibit apoptosis signal-regulating kinase 1 (ASK1) activation, also known as mitogen-activated protein kinase kinase kinase 5 (MAP3K5), as well as mitogen-activated protein kinase kinase kinase 1 (MEKK1/MAP3K1) activation to attenuate apoptosis. DJ-1 also acts on several signalling pathways to modulate autophagy such as activation of the PI3K/AKT pathway and the non-canonical MEK/ERK-mTOR Pathway and suppression of the JNK/Beclin 1 pathway.The leucine residue at position 9 of this peptide is isotopically labelled with carbon-13 (6) and nitrogen-15 (1), giving this peptide a mass increase of 7 compared to the unlabelled peptide.
Propriedades químicas
Consulta técnica sobre: 3D-CRB1300699 Protein DJ-1 (63-89) Heavy
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