Anti-SLC15A4 antibody - 0.2mg/mL
Ref. 3D-CRB2005113
| 20µg | 268,00 € | ||
| 100µg | 483,00 € |
Informação sobre produto
Solute carrier family member 15A4 (SLC15A4) is a lysosome-resident, proton-coupled histidine/oligopeptide transporter that has 12 membrane-spanning regions. SLC15A4 is expressed in haematopoietic lineage cells, including dendritic cells and B-cells, where it transports certain amino acids and oligopeptides to the cytosol, along with a proton from the inside of the late endosome/lysosome. SLC15A4 is critical for the production of type I interferon (IFN-I). SLC15A4's transporter activity is required to optimize pH and other conditions required for signalling in the late endosomes/lysosomes as well as in specialised lysosomes know as secretory granules present in mast cells. SLC15A4-mediated regulation of signalling in these compartments is an integral part of innate immune responses and may play a role in autoimmune diseases.
Propriedades químicas
Consulta técnica sobre: 3D-CRB2005113 Anti-SLC15A4 antibody - 0.2mg/mL
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