Anti-NGF antibody R1G - 1mg/mL
Ref. 3D-CRB2005711_1
| 20µg | 136,00 € |
Informação sobre produto
- crb2005711/R1G
Nerve growth factor (NGF) is a neurotrophic factor and neuropeptide involved in the regulation of specific neurons through control of neuronal growth, maintenance, proliferation, and survival. NGF protein functions as the extracellular ligand for the NTRK1 or the NGFR receptors on the surface of neurons, initiating signalling cascades inside the cell. Binding of NGF causes neurons to mature and differentiate; additionally, NGF is critical in the survival of sympathetic and sensory neurons, as in the absence of NGF these cells will undergo apoptosis.NGF is capable of binding with two classes of receptors, both tropomyosin receptor kinase A (TrkA) and low-affinity NGF receptor (LNGFR) act as ligands for NGF, activating signalling cascades. These receptors are associated with neurodegenerative diseases, implying the potential of NGF as a therapeutic drug target.
Propriedades químicas
Consulta técnica sobre: 3D-CRB2005711_1 Anti-NGF antibody R1G - 1mg/mL
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