Anti-GUCY1A2 antibody - 1mg/mL
Ref. 3D-CRB2005728
| 20µg | 136,00 € |
Informação sobre produto
Soluble guanylate cyclases (sGCs) are heterodimeric enzymes that convert GTP to 3',5'-cyclic GMP and pyrophosphate. Most complexes consist of an alpha subunit, such as alpha-2 (GUCY1A2), and a beta subunit, typically beta-1 (GUCY1B3). In the presence of magnesium or manganese ions, enzyme activity is stimulated by nitric oxide. sGCs are the principal receptors for nitric oxide (NO) and NO-releasing drugs._x000D_
_x000D_
sGC plays a role in several cardiovascular pathways. Reduced sGC function contributes to several conditions, including cardiovascular diseases. sGC-induced cGMP increase ultimately affects vascular relaxation, inhibition of platelet aggregation, and altered neurotransmission._x000D_
_x000D_
sGC GUCY1A2 is upregulated in several cancers and promotes tumorigenesis. GUCY1A2 regulation is particularly dysregulated in cervical, prostate, and gastric cancer. The expression of GUCY1A2 is proposed as a prognostic indicator for the outcome of gastric cancer and prostate cancer.
Propriedades químicas
Consulta técnica sobre: 3D-CRB2005728 Anti-GUCY1A2 antibody - 1mg/mL
Se desejar solicitar um orçamento ou fazer uma encomenda, por favor, adicione os produtos ao seu carrinho e depois solicite um orçamento ou encomenda a partir do carrinho. É mais rápido, mais barato e poderá beneficiar-se dos descontos e outras vantagens disponíveis.
