5-(2-Aminoethyl)benzene-1,2,4-triol hydrochloride

CAS: 28094-15-7

Ref. 3D-DBA09415

Informação sobre produto

• Nome: 5-(2-Aminoethyl)benzene-1,2,4-triol hydrochloride
• Sinónimos: 1,2,3-Benzenetriol, 4-(2-aminoethyl)-, hydrochloride, 1,2,4-Benzenetriol, 5-(2-aminoethyl)-, hydrochloride, 1,2,4-Benzenetriol, 5-(2-aminoethyl)-, hydrochloride (1:1), 2,4,5-Trihydroxyphenethylamine hydrochloride, 4-(2-Aminoethyl)-1,2,3-benzenetriol hydrochloride, 5-(2-Aminoethyl)-1,2,4-benzenetriol hydrochloride, 5-(2-Aminoethyl)Benzene-1,2,4-Triol Hydrochloride (1:1), 6-Hydroxydopamine chloride, 6-Hydroxydopamine hydrochloride, Nsc 233898, Oxidopamine HCl, Oxidopamine hydrochloride
• CAS: 28094-15-7

Descrição

5-(2-Aminoethyl)benzene-1,2,4-triol hydrochloride (MPP+) is a neurotoxin that inhibits the synthesis of dopamine and other neurotransmitters in dopaminergic neurons. MPP+ is generated by the oxidation of l-dopa, an amino acid precursor of the neurotransmitter dopamine. MPP+ causes oxidative injury to dopaminergic neurons by affecting their mitochondria. The inhibition of mitochondrial function leads to neuronal death and Parkinson's disease. MPP+ has been shown to be cytotoxic for pluripotent cells, such as embryonic stem cells, which are important for regenerative medicine. In addition, MPP+ has been shown to cause lesions in the brain and induce cell death in a model system using rat striatum neurons and astrocytes. This agent also inhibits polymerase chain reaction (PCR), which can be used as a diagnostic tool for Parkinson's disease.

• Marca: Biosynth

Propriedades químicas

• Peso molecular: 205.64 g/mol
• Fórmula: C₈H₁₂ClNO₃
• Pureza: Min. 95%
• Cor/forma: Powder