4-Benzoyl-1-methyl-1H-pyrrole-2-carbaldehyde
CAS: 128843-58-3
Ref. 3D-DFA84358
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Informação sobre produto
- 1H-pyrrole-2-carboxaldehyde, 4-benzoyl-1-methyl-
- 1-methyl-4-(phenylcarbonyl)-1H-pyrrole-2-carbaldehyde
4-Benzoyl-1-methyl-1H-pyrrole-2-carbaldehyde is a benzyl compound that inhibits the enzymatic activity of cytosolic phospholipase. This inhibition has been shown to suppress the synthesis of arachidonic acid, a precursor of prostaglandins and leukotrienes, which are involved in inflammatory responses. 4-Benzoyl-1-methyl-1H-pyrrole-2-carbaldehyde also inhibits the enzymatic activity of other cytosolic phospholipases, such as phospholipase A2 and D (PLA2 and PLD). The inhibitory potency for PLA2 is about 1% that for PLA4. The methyl groups in 4BzMPA are thought to function as a steric hindrance to prevent enzyme binding. The residue at position 2 is important for enzymatic activity. 4BzMPA is an inhibitor of PLA4 but not
Propriedades químicas
Consulta técnica sobre: 3D-DFA84358 4-Benzoyl-1-methyl-1H-pyrrole-2-carbaldehyde
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