Informação sobre produto
- H-Lys-His-Glu-Tyr-Leu-Arg-Phe-NH2 H-KHEYLRF-NH2
- Fmrfamidelike peptide AF2
- Lys-his-glu-tyr-leu-arg-phe-NH2
- L-Phenylalaninamide, L-lysyl-L-histidyl-L-alpha-glutamyl-L-tyrosyl-L-leucyl-L-arginyl-
- L-lysyl-3-(4H-imidazol-4-yl)-L-alanyl-L-alpha-glutamyl-L-tyrosyl-L-leucyl-N~5~-(diaminomethylidene)-L-ornithyl-L-phenylalaninamide
AF-2 is a potent, selective and competitive antagonist at the nicotinic acetylcholine receptor (nAChR). AF-2 binds to the extracellular domains of the nAChR and prevents agonists from binding. It has been shown to inhibit acetylcholine release in isolated heart preparations with high affinity and selectivity. The drug has been tested as an anthelmintic against Caenorhabditis elegans and found to be effective. AF-2 is a cholinergic compound that binds to ganglia, leading to a biphasic response. It also has significant effects on the central nervous system, inhibiting both nicotinic and muscarinic acetylcholine receptors.
AF-2 is sequenced according to the following formula:
H-Lys-His-Glu-Tyr-Leu-Arg-Phe
NH2
Propriedades químicas
Consulta técnica sobre: 3D-FA108494 AF-2
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