(D-Arg1,D-Trp7·9,Leu11)-Substance P

CAS: 91224-37-2

Ref. 3D-FA108555

Informação sobre produto

• Nome: (D-Arg1,D-Trp7·9,Leu11)-Substance P
• Sinónimos: H-D-Arg-Pro-Lys-Pro-Gln-Gln-D-Trp-Phe-D-Trp-Leu-Leu-NH2 H-(dR)PKPQQ(dW)F(dW)LL-NH2, (D-Arg1,D-Trp79,Leu11)-Substance P, H-D-Arg-Pro-Lys-Pro-Gln-Gln-D-Trp-Phe-D-Trp-Leu-Leu-NH2, D-Arg-Pro-Lys-Pro-Gln-Gln-D-Trp-Phe-D-Trp-Leu-Leu-Nh2 Hydrochloride

Descrição

Substance P is a neuropeptide that is involved in the transmission of pain signals from the nerves to the brain. It also has been implicated in inflammatory and autoimmune diseases. Substance P is a potent agonist of the neurokinin-1 receptor, which causes an increase in intracellular calcium ion levels, leading to neuronal excitation. The release of substance P from nerve fibers can be blocked by administration of an analog (e.g., N-acetyl-D-Arg1,D-Trp7·9,Leu11)-substance P H-D-Arg-Pro-Lys-Pro-Gln-Gln-D-Trp-Phe-D-Trp-Leu -Leu -NH2). This compound blocks the activation of substance P receptors with high affinity and specificity.

• Marca: Biosynth

Propriedades químicas

• Peso molecular: 1,497.79 g/mol
• Fórmula: C₇₅H₁₀₈N₂₀O₁₃
• Pureza: Min. 95%