Amyloid β peptide(1-40) trifluoroxalate - synthetic

CAS: 131438-79-4

Ref. 3D-FA110102

Informação sobre produto

• Nome: Amyloid β peptide(1-40) trifluoroxalate - synthetic
• Sinónimos: A?40 (HFIP-treated) TFA salt, L-Valine,L-a-aspartyl-L-alanyl-L-a-glutamyl-L-phenylalanyl-L-arginyl-L-histidyl-L-a-aspartyl-L-serylglycyl-L-tyrosyl-L-a-glutamyl-L-valyl-L-histidyl-L-histidyl-L-glutaminyl-L-lysyl-L-leucyl-L-valyl-L-phenylalanyl-L-phenylalanyl-L-alanyl-L-a-glutamyl-L-a-aspartyl-L-valylglycyl-L-seryl-L-asparaginyl-L-lysylglycyl-L-alanyl-L-isoleucyl-L-isoleucylglycyl-L-leucyl-L-methionyl-L-valylglycylglycyl-L-valyl-, Amyloidb-peptide(1-40)(human), H-asp-ala-glu-phe-gly-his-asp-ser-gly-phe-glu-val-arg-his-asp-ser-gly-phe-glu-val-arg-his-gln-lys-leu-val-gly-phe-phe-ala-glu-asp-val-gly-ser-asn-lys-gly-ala-ile-ile-gly-leu-met-val-gly-gly-val-val-oh, ss-Amyloid (1-40), rat, Beta-Amyloid Protein(1-40), Beta-Amyloid 1-40,human, Abeta 1-40, β-Amyloid(1-40)Human

Descrição

Amyloid beta peptide (Aβ) is a neurotrophic factor that is involved in the pathogenic mechanism of Alzheimer's disease. This drug inhibits the production of Aβ by binding to the enzyme, secretase. It has been shown that Aβ binds to a transporter protein and is transported into cells, where it accumulates in the cytoplasm. The physiological levels of Aβ are regulated by proteins called "gene chaperones" which prevent Aβ from aggregating into plaques. Dextran sulfate inhibits this process by binding to amyloid and preventing it from accumulating in the cytoplasm. Amyloid beta peptide trifluoroxalate (ATFX) has been shown to inhibit the production of Aβ with structural analysis, inhibition of cellular uptake and secretion, and inhibition of fibrillization. ATFX also has potential as a biomarker for Alzheimer's disease because it can be detected at low concentrations in urine or serum

• Marca: Biosynth

Propriedades químicas

• Peso molecular: 4,443.83 g/mol
• Fórmula: C₁₉₄H₂₉₅N₅₃O₅₈S·C₂HF₃O₂
• Pureza: Min. 95%
• Cor/forma: White Powder