N-Acetyl amonafide
CAS:
Ref. 3D-FA17012
Informação sobre produto
Nome:N-Acetyl amonafide
Sinónimos:
- N-[2-[2-(Dimethylamino)ethyl]-2,3-dihydro-1,3-dioxo-1H-benz[de]isoquinolin-5-yl]acetamideMADE-FA 4512N-Acetylamonafide
Marca:Biosynth
Descrição:N-Acetyl amonafide (NAA) is a potent antitumor agent that has shown activity against urothelial carcinoma, prostate cancer cells and skin cancer. It is an inhibitor of the uptake and efflux of anticancer drugs in tumor cells. NAA inhibits the growth of prostate cancer cells by inhibiting protein synthesis through inhibition of protein tyrosine phosphatase (PTP) activity. This drug has been shown to be effective in inhibiting the growth of human fetal bovine kidney cells and inducing apoptosis in these cells. NAA also inhibits the proliferation of human bladder cancer cells in culture by inhibiting DNA synthesis and causing cell cycle arrest. The molecular docking analysis revealed that NAA binds to topoisomerase II alpha, which is an enzyme involved in DNA replication, repair and transcription.
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Propriedades químicas
Peso molecular:325.36 g/mol
Fórmula:C18H19N3O3
Pureza:Min. 95%