Acetylisoniazide

CAS: 1078-38-2

Ref. 3D-FA17025

Informação sobre produto

• Nome: Acetylisoniazide
• Sinónimos: 2-Acetylhydrazide-4-pyridinecarboxylic acid1-Acetyl-2-isonicotinoylhydrazideAcetyl isoniazid, 1-Acetyl-2-isonicotinoylhydrazine, 4-Pyridinecarboxylic acid, 2-acetylhydrazide, Acetylisoniazid, Hydrazine, 1-acetyl-2-isonicotinoyl-, Hydrazine,1-Acetyl-2-Isonicotinyl-, N'-acetylpyridine-4-carbohydrazide, N-Acetyl-N′-isonicotinoylhydrazine, N-Acetylisoniazid, N-Acetylisonicotinylhydrazide, N-Monoacetylisoniazid, NSC 36084

Descrição

Acetylisoniazide is an antimicrobial agent that belongs to the group of enzyme inducers. It is a prodrug that is hydrolyzed by esterases in the body to picolinic acid and acetyl-CoA. Acetylisoniazide has been shown to inhibit the growth of bacteria, yeast, and fungi that are resistant to other antimicrobial agents. This drug also inhibits the production of pyrazinoic acid, a metabolite of tryptophan synthesis and an activator of macrophages. Acetylisoniazide has been shown to have a synergistic effect with isoniazid for the treatment of tuberculosis. The polymerase chain reaction (PCR) method was used for this study. Acetylisoniazide binds to human serum albumin, which decreases its solubility in water and affects its reactivity with fluorescence probes. The matrix effect was investigated using rat liver microsomes as a model system.

• Marca: Biosynth

Propriedades químicas

• Peso molecular: 179.18 g/mol
• Fórmula: C₈H₉N₃O₂
• Pureza: Min. 95 Area-%
• Cor/forma: Powder
• InChI: InChI=1S/C8H9N3O2/c1-6(12)10-11-8(13)7-2-4-9-5-3-7/h2-5H,1H3,(H,10,12)(H,11,13)
• Chave InChI: InChIKey=CVBGNAKQQUWBQV-UHFFFAOYSA-N
• SMILES: CC(=O)NNC(=O)c1ccncc1