Dabrafenib

CAS: 1195765-45-7

Ref. 3D-FA65034

Informação sobre produto

• Nome: Dabrafenib
• Sinónimos: N-(3-(5-(2-Aminopyrimidine-4-yl)-2-tert-butylthiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamideGSK2118436A
• Marca: Biosynth
• Descrição: Inhibitor of mutant B-rafV600E protein that results in decreased proliferation of cancer cells with this mutation. Treatment of metastatic melanoma in patients harboring the V600E mutation, had improved disease outcome. This antitumor activity is enhanced when combined with MEK inhibitor trametinib.

Propriedades químicas

• Peso molecular: 519.56 g/mol
• Fórmula: C₂₃H₂₀F₃N₅O₂S₂
• Pureza: Min. 95%
• Cor/forma: Powder
• InChI: InChI=1S/C23H20F3N5O2S2/c1-23(2,3)21-30-18(19(34-21)16-10-11-28-22(27)29-16)12-6-4-9-15(17(12)26)31-35(32,33)20-13(24)7-5-8-14(20)25/h4-11,31H,1-3H3,(H2,27,28,29)
• Chave InChI: InChIKey=BFSMGDJOXZAERB-UHFFFAOYSA-N
• SMILES: CC(C)(C)c1nc(-c2cccc(NS(=O)(=O)c3c(F)cccc3F)c2F)c(-c2ccnc(N)n2)s1