Informação sobre produto
- Ai3-52508
- Brn 2806929
- Ccris 6985
- Nsc 14764
- 2-Chrysenamine
- Chrysen-2-Amine
2-Aminochrysene is a chemical that binds to DNA and causes a genotoxic effect. It has been shown to be carcinogenic to rats and is carcinogenic in humans. 2-Aminochrysene is metabolized by conjugation with glucuronic acid or glutathione, which are found in the liver, kidney, and other tissues. The binding constants for 2-aminochrysene were measured using the calf thymus DNA as a substrate and amines as ligands. Transfer of 2-aminochrysene from the plasma membrane to the cytosol was observed in cells treated with nitrous oxide (NO). The cytosolic enzyme binding assay showed that 2-aminochrysene binds to the S9 protein of hepatic microsomes.
2-Aminochrysene has also been shown to inhibit phospholipase A2 activity, which may be due to its ability to bind to the enzyme's active site.
Propriedades químicas
Consulta técnica sobre: 3D-FA66865 2-Aminochrysene
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