5-Bromo-2,4-dichloropyrimidine

CAS: 36082-50-5

Ref. 3D-FB10261

Informação sobre produto

• Nome: 5-Bromo-2,4-dichloropyrimidine
• Sinónimos: 2,4-Dichloro-5-bromo pyrimidine, 2,4-Dichloro-5-bromopyrimidine, 2,6-Dichloro-5-bromopyrimidine, 5-Bromo-2,4-Dichloropyridimidine, 5-Bromo-2,6-dichloropyrimidine, Buttpark 48\06-22, NSC 152517, Pyrimidine, 5-bromo-2,4-dichloro-, Timtec-Bb Sbb003301
• CAS: 36082-50-5

Descrição

5-Bromo-2,4-dichloropyrimidine is an aryl halide compound that is synthesized from 2,4-dichloropyrimidine and bromine. It has been shown to have inhibitory activities against cancer cells in vitro. 5-Bromo-2,4-dichloropyrimidine is used in the synthesis of the drug palbociclib (also known as PLX4720), which prevents mitotic progression by binding to the mitotic checkpoint protein (e.g., cyclin B). The reaction yield for this compound is low and its absorption enhancer properties are not well understood. 5-Bromo-2,4-dichloropyrimidine has also been used in conjunction with crotonic acid as a potential anticancer agent.

• Marca: Biosynth

Propriedades químicas

• Peso molecular: 227.87 g/mol
• Fórmula: C₄HBrCl₂N₂
• Pureza: Min. 95%
• Cor/forma: Off-White Clear Liquid
• InChI: InChI=1S/C4HBrCl2N2/c5-2-1-8-4(7)9-3(2)6/h1H
• Chave InChI: InChIKey=SIKXIUWKPGWBBF-UHFFFAOYSA-N
• SMILES: Clc1ncc(Br)c(Cl)n1