6-Chloro-imidazo[1,2-b]pyridazine

CAS: 6775-78-6

Ref. 3D-FC11286

Informação sobre produto

• Nome: 6-Chloro-imidazo[1,2-b]pyridazine
• Sinónimos: 6-Chloroimidazo[2,1-f]pyridazine

Descrição

6-Chloro-imidazo[1,2-b]pyridazine (6CI) is a potent inhibitor of the VEGF pathway. It inhibits the production of TNF-α and other inflammatory mediators by targeting the tumor necrosis factor receptor type 1 (TNFR1). 6CI has been shown to inhibit factor receptor activation in vitro, suggesting that it may also have an inhibitory effect on other receptors. These results suggest that 6CI can be used to treat inflammatory diseases such as rheumatoid arthritis.
6CI has been shown to bind to various halides, which may be due to the presence of hydrogen bonds. The molecular modeling studies show that the hydrogen bond stabilizes the binding between 6CI and TNFR1 and prevents this interaction from occurring with its natural ligand, VEGF.

• Marca: Biosynth

Propriedades químicas

• Peso molecular: 153.57 g/mol
• Fórmula: C₆H₄ClN₃
• Pureza: Min. 95%
• Cor/forma: White to off white crystalline powder
• InChI: InChI=1S/C6H4ClN3/c7-5-1-2-6-8-3-4-10(6)9-5/h1-4H
• Chave InChI: InChIKey=MPZDNIJHHXRTIQ-UHFFFAOYSA-N
• SMILES: Clc1ccc2nccn2n1