4-(Chloromethyl)-7-hydroxy-2H-chromen-2-one
CAS: 25392-41-0
Ref. 3D-FC117486
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Informação sobre produto
- 2H-1-benzopyran-2-one, 4-(chloromethyl)-7-hydroxy-
- 4-(chloromethyl)-7-hydroxy-2H-chromem-2-one
4-(Chloromethyl)-7-hydroxy-2H-chromen-2-one (CMHC) is a cytostatic agent that inhibits the synthesis of DNA and RNA. It also has antimicrobial activity, which is due to its inhibition of bacterial protein synthesis. CMHC has been shown to be effective against cancer cells in vitro and in vivo. The cytostatic effects of this drug are mediated by inhibition of dna replication, which leads to arrest at the G1 phase. This drug also inhibits aromatase and carbonic anhydrase enzymes. CMHC binds to subunits of the human CD4+ T cell receptor, leading to a decrease in regulatory T cells and an increase in proinflammatory cytokine production. The anticancer activity of CMHC can be increased by coadministration with ammonium nitrate or other regulatory agents such as antimicrobial agents.
Propriedades químicas
Consulta técnica sobre: 3D-FC117486 4-(Chloromethyl)-7-hydroxy-2H-chromen-2-one
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