6-Cyclopropyl-8-fluoroisoquinolin-1(2H)-one
CAS: 1242156-53-1
Ref. 3D-FC161324
| 5mg | Descontinuado | ||
| 10mg | Descontinuado | ||
| 25mg | Descontinuado | ||
| 50mg | Descontinuado | ||
| 100mg | Descontinuado |
Informação sobre produto
Nome:
6-Cyclopropyl-8-fluoroisoquinolin-1(2H)-one
Descrição:
6-Cyclopropyl-8-fluoroisoquinolin-1(2H)-one is a potent and selective inhibitor of tyrosine kinases. The compound was discovered by screening for inhibitors of the PDGF receptor in a cellular assay. The structure activity relationship analysis revealed that the 6-cyclopropyl group and 8-fluoroisoquinoline moiety are critical for the inhibitory potency and selectivity. In particular, the 8-fluoroisoquinoline moiety is important for binding to the ATP site on PDGFRs, as well as for binding to other tyrosine kinases such as c-Met, c-Kit, cRaf, cSrc, and EGFR. 6-Cyclopropyl-8-fluoroisoquinolin-1(2H)-one has been shown to have potential therapeutic applications in rheumatoid arthritis by inhibiting the production of proinflammatory cytokines in
Aviso:
Os nossos productos estão destinados exclusivamente para uso em laboratório. Para qualquer outra aplicação, por favor entre em contacto.
Marca:
Biosynth
Armazenamento a longo prazo:
Notas:
Propriedades químicas
Peso molecular:
203.21 g/mol
Fórmula:
C12H10FNO
Pureza:
Min. 95%
InChI:
InChI=1S/C12H10FNO/c13-10-6-9(7-1-2-7)5-8-3-4-14-12(15)11(8)10/h3-7H,1-2H2,(H,14,15)
Chave InChI:
InChIKey=LDOIRSRUYDIUTP-UHFFFAOYSA-N
SMILES:
O=c1[nH]ccc2cc(C3CC3)cc(F)c12
MDL:
Ponto de fusão:
Ponto de ebulição:
Ponto de inflamação:
Densidade:
Concentração:
EINECS:
Merck:
Código HS:
