Cyclopamine

CAS: 4449-51-8

Ref. 3D-FC20718

Informação sobre produto

• Nome: Cyclopamine
• Sinónimos: (2'R,3S,3'R,3'aS,6'S,6aS,6bS,7'aR,11aS,11bR)-1,2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11,11a,11b-Octadecahydro-3',6',10,11b-tetrameth ylspiro[9H-benzo[a]fluorene-9,2'(3'H)-furo[3,2-b]pyridin]-3-ol, (2′R,3S,3′R,3′aS,6′S,6aS,6bS,7′aR,11aS,11bR)-1,2,3,3′a,4,4′,5′,6,6′,6a,6b,7,7′,7′a,8,11,11a,11b-Octadecahydro-3′,6′,10,11b-tetramethylspiro[9H-benzo[a]fluorene-9,2′(3′H)-furo[3,2-b]pyridin]-3-ol, (3beta,22S,23R)-17,23-epoxyveratraman-3-ol, 11-Deoxojervine, 11-Deoxyjervine, Hsdb 3505, Jervine, 11-deoxo-, Jervine, 11-deoxo- (7CI), Spiro(9H-benzo(a)fluorene-9,2'(3'H)-furo(3,2-b)pyridin)-3-ol, 1,2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11,11a,11b-octadecahydro-3',6',10,11b-tetramethyl-, (2'R,3S,3'R,3'aS,6'S,6aS,6bS,7'aR,11aS,11bR)-, Spiro[9H-benzo[a]fluorene-9,2′(3′H)-furo[3,2-b]pyridin]-3-ol, 1,2,3,3′a,4,4′,5′,6,6′,6a,6b,7,7′,7′a,8,11,11a,11b-octadecahydro-3′,6′,10,11b-tetramethyl-, (2′R,3S,3′R,3′aS,6′S,6aS,6bS,7′aR,11aS,11bR)-, Veratraman-3-ol, 17,23-epoxy-, (3-beta,23-beta)- (9CI), Veratraman-3-ol, 17,23-epoxy-, (3beta,23beta)-, Veratraman-3-ol, 17,23-epoxy-, (3β,23β)-

Descrição

Inhibitor of the Smoothened receptor and Hedgehog signalling pathway. Cyclopamine is a steroidal alkaloid that binds to the heptahelical bundle of Smoothened and negatively regulates transcription of downstream genes. In prostate cancer cells, cyclopamine inhibited cell growth, arrested cell cycle and in glioblastoma, it depleted stem cell-like cancer cells.

• Marca: Biosynth

Propriedades químicas

• Peso molecular: 411.31373
• Fórmula: C₂₇H₄₁NO₂
• Pureza: Min. 95%
• Cor/forma: White Solid