(+)-JQ 1

CAS: 1268524-70-4

Ref. 3D-FC43273

Informação sobre produto

• Nome: (+)-JQ 1
• Sinónimos: [(S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-1-thia-5,7,8,9a-tetraaza-cyclopenta[e]azulen-6-yl]-acetic acid tert-butyl ester(S)-(
• Marca: Biosynth
• Descrição: Potent BET inhibitor with high specificity for acetyl-lysine recognition motifs found in the BET family (Brd2, Brd3, Brd4, Brdt). Engages with bromodomain pocket and competes with acetylated peptide binding, causing displacement of BET proteins from chromatin and disrupting transcription. Has been used in clinical trials as chemotherapy and male contraceptive.

Propriedades químicas

• Peso molecular: 456.99 g/mol
• Fórmula: C₂₃H₂₅ClN₄O₂S
• Pureza: Min. 95%
• Cor/forma: White Powder
• InChI: InChI=1S/C23H25ClN4O2S/c1-12-13(2)31-22-19(12)20(15-7-9-16(24)10-8-15)25-17(11-18(29)30-23(4,5)6)21-27-26-14(3)28(21)22/h7-10,17H,11H2,1-6H3/t17-/m0/s1
• Chave InChI: InChIKey=DNVXATUJJDPFDM-KRWDZBQOSA-N
• SMILES: Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)OC(C)(C)C)c1nnc(C)n1-2