N-(4-{[(2,4-Diamino-6-pteridinyl)methyl]amino}-3-fluorobenzoyl)-L-glutamic acid

CAS: 85803-34-5

Ref. 3D-FD100478

Informação sobre produto

• Nome: N-(4-{[(2,4-Diamino-6-pteridinyl)methyl]amino}-3-fluorobenzoyl)-L-glutamic acid

Descrição

N-(4-{[(2,4-Diamino-6-pteridinyl)methyl]amino}-3-fluorobenzoyl)-L-glutamic acid is a cytotoxic agent that inhibits the growth of cancer cells. It has shown cytotoxicity in both human and bacterial cell lines. This compound is a potent inhibitor of DNA synthesis and RNA synthesis, which may be responsible for its cytotoxic effects. N-(4-{[(2,4-Diamino-6-pteridinyl)methyl]amino}-3-fluorobenzoyl)-L-glutamic acid is an analog of aminopterin, which was used in the treatment of leukemia before being replaced by other drugs. It also binds to DNA and protein in a manner similar to pteridine.

• Marca: Biosynth

Propriedades químicas

• Peso molecular: 458.4 g/mol
• Fórmula: C₁₉H₁₉FN₈O₅
• Pureza: Min. 95%
• InChI: InChI=1S/C19H19FN8O5/c20-10-5-8(17(31)26-12(18(32)33)3-4-13(29)30)1-2-11(10)23-6-9-7-24-16-14(25-9)15(21)27-19(22)28-16/h1-2,5,7,12,23H,3-4,6H2,(H,26,31)(H,29,30)(H,32,33)(H4,21,22,24,27,28)/t12-/m0/s1
• Chave InChI: InChIKey=SGJMILOGOMOIPG-LBPRGKRZSA-N
• SMILES: Nc1nc(N)c2nc(CNc3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc3F)cnc2n1