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3,5-Dibromopyrazin-2-ol
CAS: 21943-15-7
Ref. 3D-FD139570
2g | A consultar | ||
5g | A consultar | ||
10g | A consultar | ||
25g | A consultar | ||
50g | A consultar |
Informação sobre produto
- 2(1H)-Pyrazinone, 3,5-dibromo-
- 3,5-Bromopyrazin-2-Ol
- 3,5-Dibromo-1,2-dihydropyrazin-2-one
- 3,5-Dibromo-1H-pyrazin-2-one
- 3,5-Dibromo-2(1H)-pyrazinone
- 3,5-Dibromo-Pyrazin-2-Ol
- 3,5-Dibromopyrazin-2-Ol
- Pyrazinol, 3,5-dibromo-
3,5-Dibromopyrazin-2-ol is a synthetic compound that has been found to be an inhibitor of the polymerization of tubulin. It is also a modulator of hydration and has been found to be effective against rhabdomyosarcoma cells. 3,5-Dibromopyrazin-2-ol inhibits the growth of human rhabdomyosarcoma cells in vitro and in vivo. It interacts with the hydroxyl group on the 2' position of ribose in RNA and inhibits protein synthesis by binding to the ribose moiety at the active site of tubulin polymerase. This binding prevents the formation of an enzyme-substrate complex that is required for polymerization. 3,5-Dibromopyrazin-2-ol also disrupts microtubule assembly by preventing nucleotide addition to tubulin at the plus end of microtubules, which leads to depolymerization.
Propriedades químicas
Consulta técnica sobre: 3D-FD139570 3,5-Dibromopyrazin-2-ol
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