3',4'-Dihydroxyetoposide
CAS: 100007-54-3
Ref. 3D-FD21267
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Informação sobre produto
- 3',4'-Dihydroxy-VP 16-213
- Dhvp-16-213
- Furo(3',4':6,7)naphtho(2,3-d)-1,3-dioxol-6(5aH)-one, 5-(3,4-dihydroxy-5-methoxyphenyl)-9-((4,6-O-ethylidene-beta-D-glucopyranosyl)oxy)-5,8,8a,9-tetrahydro-, (5R-(5alpha,5abeta,8aalpha,9beta(R*)))-
- (5S,5aR,8aR,9R)-9-(3,4-dihydroxy-5-methoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl 4,6-O-[(1R)-ethylidene]-beta-D-glucopyranoside
3',4'-Dihydroxyetoposide is an anti-cancer agent that belongs to the group of epipodophyllotoxins. It inhibits DNA synthesis and cell division by binding to topoisomerase II, leading to DNA breakage and the formation of single-stranded breaks. 3',4'-Dihydroxyetoposide has been shown to be safe for use in children with leukemia, although it is not active against cells without a nucleus, such as erythrocytes. This drug also has significant inhibition of human cytochrome P450 3A4 (CYP3A4) and human liver microsomes.
Propriedades químicas
Consulta técnica sobre: 3D-FD21267 3',4'-Dihydroxyetoposide
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