O-Desmethyl indomethacin

CAS: 2504-32-7

Ref. 3D-FD21281

Informação sobre produto

• Nome: O-Desmethyl indomethacin
• Sinónimos: 1-(4-Chlorobenzoyl)-5-hydroxy-2-methyl-1H-indole-3-acetic acid5-HydroxyindomethacinDemethylindomethacin
• Marca: Biosynth
• Descrição: O-Desmethyl indomethacin is a metabolite of indomethacin that has been shown to be a potent cytotoxic agent and may have potential as an anticancer drug. It inhibits the mitochondrial membrane potential in HL60 cells, which causes significant cytotoxicity. The target tissue for O-desmethyl indomethacin is not known, but it has been shown to be effective against cancer cells in clinical studies. O-Desmethyl indomethacin binds to glucocorticoid receptors in the cytoplasm and inhibits organic anion transporters, leading to its accumulation in urine samples. Studies have also shown that O-desmethyl indomethacin is excreted by infants through breast milk and eliminated with other metabolites through the preparative high performance liquid chromatography (HPLC).

Propriedades químicas

• Peso molecular: 343.76 g/mol
• Fórmula: C₁₈H₁₄ClNO₄
• Pureza: Min. 95%
• InChI: InChI=1S/C18H14ClNO4/c1-10-14(9-17(22)23)15-8-13(21)6-7-16(15)20(10)18(24)11-2-4-12(19)5-3-11/h2-8,21H,9H2,1H3,(H,22,23)
• Chave InChI: InChIKey=KMLNWQPYFBIALN-UHFFFAOYSA-N
• SMILES: Cc1c(CC(=O)O)c2cc(O)ccc2n1C(=O)c1ccc(Cl)cc1