N-Desmethyl topotecan
CAS: 190710-79-3
Ref. 3D-FD21332
| 1mg | Descontinuado | ||
| 2mg | Descontinuado | ||
| 100µg | Descontinuado | ||
| 250µg | Descontinuado | ||
| 500µg | Descontinuado |
Informação sobre produto
Nome:
N-Desmethyl topotecan
Sinónimos:
- (4S)-4-Ethyl-4,9-dihydroxy-10-[(methylamino)methyl]-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
Descrição:
Topotecan is a camptothecin derivative that inhibits topoisomerase I, which is an enzyme that maintains the integrity of DNA. It binds to DNA and prevents the separation of two strands, leading to cell death by inhibiting protein synthesis. Topotecan has been shown to be effective in the treatment of primary brain tumors and solid tumours, as well as urinary tract cancers. Side effects include drug interactions and concomitant use with other anticancer drugs. Topotecan has a carboxylate group at one end of its molecule that can bind to tissue samples such as liver tissue or urine samples from patients with bladder cancer. This allows for chromatographic separation, which can be used to measure drug levels in tissues or urine samples.
Aviso:
Os nossos productos estão destinados exclusivamente para uso em laboratório. Para qualquer outra aplicação, por favor entre em contacto.
Marca:
Biosynth
Armazenamento a longo prazo:
Notas:
Propriedades químicas
Peso molecular:
407.42 g/mol
Fórmula:
C22H21N3O5
Pureza:
Min. 95%
InChI:
InChI=1S/C22H21N3O5/c1-3-22(29)15-7-17-19-11(9-25(17)20(27)14(15)10-30-21(22)28)6-12-13(8-23-2)18(26)5-4-16(12)24-19/h4-7,23,26,29H,3,8-10H2,1-2H3/t22-/m0/s1
Chave InChI:
InChIKey=ZWUJOGCYOWLZFL-QFIPXVFZSA-N
SMILES:
CC[C@@]1(O)C(=O)OCc2c1cc1n(c2=O)Cc2cc3c(CNC)c(O)ccc3nc2-1
MDL:
Ponto de fusão:
Ponto de ebulição:
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Merck:
Código HS:
