2,5-Diamino-2,3-dihydrothiazolo[4,5-d]pyrimidine-7-(6H)-one

CAS: 22288-77-3

Ref. 3D-FD21449

Informação sobre produto

• Nome: 2,5-Diamino-2,3-dihydrothiazolo[4,5-d]pyrimidine-7-(6H)-one
• Sinónimos: 2,5-Diamino-thiazolo[4,5-d]pyrimidin-7(4H)-one

Descrição

2,5-Diamino-2,3-dihydrothiazolo[4,5-d]pyrimidine-7-(6H)-one is an inhibitor of nucleoside phosphorylase. It has been shown to inhibit the growth of myeloid leukemia cells in culture. This drug may have a potential use in the treatment of T-cell leukemia and other malignancies involving purine metabolism. 2,5-Diamino-2,3-dihydrothiazolo[4,5-d]pyrimidine-7-(6H)-one is an analogue of 8-aminoguanine (8AG), which is a substrate for nucleoside phosphorylase. The enzyme converts 8AG into guanosine triphosphate (GTP) and purine nucleosides. The enzyme also converts purine nucleosides into their corresponding ribonucleotides. These ribonucleotides are

• Marca: Biosynth

Propriedades químicas

• Peso molecular: 183.19 g/mol
• Fórmula: C₅H₅N₅OS
• Pureza: Min. 95%
• InChI: InChI=1S/C5H5N5OS/c6-4-8-2-1(3(11)10-4)12-5(7)9-2/h(H5,6,7,8,9,10,11)
• Chave InChI: InChIKey=QWAUZOMMNINGON-UHFFFAOYSA-N
• SMILES: Nc1nc2nc(N)sc2c(=O)[nH]1