Mertansine

CAS: 139504-50-0

Ref. 3D-FD33453

Informação sobre produto

• Nome: Mertansine
• Sinónimos: N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine DM 1Maytansinoid DM 1, DM 1, N2′-Deacetyl-N2′-(3-mercapto-1-oxopropyl)maytansine, Maytansine, N2′-deacetyl-N2′-(3-mercapto-1-oxopropyl)-, Maytansinoid DM 1

Descrição

N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine is a thiol-containing derivative of maytansine. Maytansine and its derivatives kill cells by interfering with the formation of microtubules, and causing the depolymerisation of already formed microtubules. Antibody conjugates of N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine and the murine monoclonal antibody TA. 1, using linkers containing either a disulfide bond or a thioether bond, have been synthesised. These antibody conjugates bind to the HER-2/new oncogene protein that is expressed on human breast tumor cells.

• Marca: Biosynth

Propriedades químicas

• Peso molecular: 738.29 g/mol
• Fórmula: C₃₅H₄₈ClN₃O₁₀S
• Pureza: Min. 95%
• Cor/forma: White Off-White Yellow Powder