Informação sobre produto
- Efegatran [INN]
- Ly 294468
- Unii-Vt0Vk2474K
- L-Prolinamide, N-methyl-D-phenylalanyl-N-(4-((aminoiminomethyl)amino)-1-formylbutyl)-, (S)-
- N-methyl-D-phenylalanyl-N-{(2S)-5-[(diaminomethylidene)amino]-1-oxopentan-2-yl}-L-prolinamide
Efegatran is a chemical compound that has a number of clinical indications, including the treatment of congestive heart failure, hypertension, and thrombosis. It is an inhibitor of platelet aggregation and prevents the binding of heparin to platelets. Efegatran reduces blood pressure by inhibiting angiotensin-converting enzyme (ACE), which in turn blocks the conversion of angiotensin I to angiotensin II. Efegatran also inhibits the production of erythrocytes, leading to intravascular hemolysis. The plasma concentration of efegatran can be monitored with a monoclonal antibody (Mab) that binds to activated efegatran. In these experiments, Mab binding was measured using radio-labelled 125I-labelled efegatran as a tracer.
Propriedades químicas
Consulta técnica sobre: 3D-FE163232 Efegatran
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