5,6-Epoxy-13-cis retinoic acid
CAS: 81444-57-7
Ref. 3D-FE22755
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Informação sobre produto
- 13-cis-5,6-Epoxy-5,6-dihydroretinoic acid
5,6-Epoxy-13-cis retinoic acid (5,6-ER) is the most active metabolite of all-trans-retinoic acid. 5,6-ER binds to the nuclear receptor and acts as a transcription factor. It has been shown to inhibit the growth of several cancer cell lines in vitro, including T47D cells. 5,6-ER also has antacid properties and can be used for the treatment of inflammatory bowel disease. 5,6-ER is found in low concentrations in plasma and tissues and accumulates in high concentrations in rat liver microsomes. The major metabolic pathway includes hydrolysis by trifluoroacetic acid which produces 5,6 epoxyretinoyl coenzyme A (5,6 epoxyretinoyl CoA). This compound is then converted to 5,6 epoxyretinol by an unknown mechanism.
Propriedades químicas
Consulta técnica sobre: 3D-FE22755 5,6-Epoxy-13-cis retinoic acid
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