Estrone 3-O-sulfamate

CAS: 148672-09-7

Ref. 3D-FE22840

Informação sobre produto

• Nome: Estrone 3-O-sulfamate
• Sinónimos: 3-[(Aminosulfonyl)oxy]estra-1,3,5(10)-trien-17-oneEMATEEstrone 3-sulfamate, 3-((Aminosulfonyl)oxy)estra-1,3,5(10)-trien-17-one, Emate compound, Estra-1,3,5(10)-trien-17-one-3-sulfamate, Oestrone-3-O-sulphamate, Estra-1,3,5(10)-trien-17-one, 3-((aminosulfonyl)oxy)-, 17-Oxoestra-1,3,5(10)-Trien-3-Yl Sulfamate

Descrição

Estrone 3-O-sulfamate is a sulfamoylating agent that inhibits the enzyme aromatase, which is responsible for converting androgenic hormones to oestrogen. The irreversible inhibition of this enzyme leads to decreased oestrogen levels in the body. Estrone 3-O-sulfamate has been shown to be effective against solid tumours in mice, as well as breast cancer cell lines in vitro. It binds reversibly to the sulfhydryl group of cysteine residues on the enzyme and irreversibly inhibits its activity by forming a covalent bond with the sulfur atom in cysteine. This prevents the formation of an enzyme-substrate complex and prevents synthesis of oestrone from androgenic hormones.

• Marca: Biosynth

Propriedades químicas

• Peso molecular: 349.45 g/mol
• Fórmula: C₁₈H₂₃NO₄S
• Pureza: Min. 95%
• Cor/forma: Powder