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4-[4-[[5-Fluoro-4-[[3-[(1-oxo-2-propen-1-yl)amino]phenyl]amino]-2-pyrimidinyl]amino]phenoxy]-N-methyl-2-pyridinecarboxamide
CAS: 1202759-32-7
Ref. 3D-FF103464
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Informação sobre produto
4-[4-[[5-Fluoro-4-[[3-[(1-oxo-2-propen-1-yl)amino]phenyl]amino]-2-pyrimidinyl]amino]phenoxy]-N-methylpyridinecarboxamide (SMX) is a sulfonamide analog that inhibits bacterial efflux pumps and has been shown to be effective against carbapenem resistant bacteria. SMX specifically binds to the protein in the bacterial cell membrane that pumps drugs out of the cell and prevents it from functioning. The structural formula of SMX was determined by NMR spectroscopy, while its sequence was determined by DNA sequencing. SMX has been shown to be active against a wide range of bacterial strains, including methicillin resistant Staphylococcus aureus, with minimal inhibitory concentrations ranging from 0.06 to 2 µg/ml for most strains tested. It also shows high specificity for Gram
Propriedades químicas
Consulta técnica sobre: 3D-FF103464 4-[4-[[5-Fluoro-4-[[3-[(1-oxo-2-propen-1-yl)amino]phenyl]amino]-2-pyrimidinyl]amino]phenoxy]-N-methyl-2-pyridinecarboxamide
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