6-Fluoroquinoline
CAS: 396-30-5
Ref. 3D-FF42187
| 2g | A consultar | ||
| 5g | A consultar | ||
| 10g | A consultar | ||
| 25g | A consultar | ||
| 50g | A consultar |
Informação sobre produto
- Brn 0112962
- Ccris 2892
- Quinoline, 6-fluoro-
6-Fluoroquinoline is a pyrazole compound that has been studied clinically for the treatment of tuberculosis. It is a potent inhibitor of Ido1, an enzyme that catalyzes the final step in the biosynthesis of the dTMP precursor required for DNA replication and repair. 6-Fluoroquinoline is also a multidrug resistance (MDR) inhibitor. The hydroxyl group on its 6 position makes it more reactive than other fluoroquinolones, allowing it to react with cellular nucleophiles such as thiols and amines. This reaction leads to inhibition of MDR protein pumps and subsequent cell death. 6-Fluoroquinoline has shown efficacy against clinical strains of Mycobacterium tuberculosis, including drug-resistant strains, but not against clinical isolates of Mycobacterium avium complex or Mycobacterium kansasii.
Propriedades químicas
Consulta técnica sobre: 3D-FF42187 6-Fluoroquinoline
Se desejar solicitar um orçamento ou fazer uma encomenda, por favor, adicione os produtos ao seu carrinho e depois solicite um orçamento ou encomenda a partir do carrinho. É mais rápido, mais barato e poderá beneficiar-se dos descontos e outras vantagens disponíveis.
