2-(Fluoromethyl)-Ornithine

CAS: 73800-85-8

Ref. 3D-FF78253

Informação sobre produto

• Nome: 2-(Fluoromethyl)-Ornithine
• Sinónimos: Ornithine, 2-(Fluoromethyl)-

Descrição

2-(Fluoromethyl)-Ornithine (2-FMEO) is a potent antitumor agent that is an irreversible inhibitor of polyamine biosynthesis. It has been shown to inhibit the growth of cancer cells and other tumor cells in experimental models. 2-FMEO inhibits the enzyme ornithine decarboxylase, which converts ornithine to putrescine, by binding reversibly to the nitrogen atom in the active site. This inhibition leads to a depletion of polyamines, which are necessary for cell growth. 2-FMEO also inhibits spermidine synthase and spermidine/spermine N1-acetyltransferase, which are enzymes involved in the synthesis of spermidine and spermine from putrescine.

• Marca: Biosynth

Propriedades químicas

• Peso molecular: 164.18 g/mol
• Fórmula: C₆H₁₃FN₂O₂
• Pureza: Min. 95%
• InChI: InChI=1S/C6H13FN2O2/c7-4-6(9,5(10)11)2-1-3-8/h1-4,8-9H2,(H,10,11)
• Chave InChI: InChIKey=PYSFCFGTQFSVRE-UHFFFAOYSA-N
• SMILES: NCCCC(N)(CF)C(=O)O