4-Hydroperoxy cyclophosphamide

CAS: 39800-16-3

Ref. 3D-FH23893

Informação sobre produto

• Nome: 4-Hydroperoxy cyclophosphamide
• Sinónimos: 2-[Bis(2-chloroethyl)amino]tetrahydro-2-oxido-2H-1,3,2-oxazaphosphorin-4-yl hydroperoxidePerfosfamide4-HC, (2R,4R)-2-[bis(2-chloroethyl)amino]-2-oxido-1,3,2-oxazaphosphinan-4-yl hydroperoxide, 2-[Bis(2-chloroethyl)amino]tetrahydro-2-oxido-2H-1,3,2-oxazaphosphorin-4-yl hydroperoxide, 2H-1,3,2-Oxazaphosphorine, hydroperoxide deriv., 4-Hydroperoxycyclofosfamide, 4-Hydroperoxycyclophosphamide, Asta 6496, Hydroperoxide, 2-[bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorin-4-yl, P-oxide, hydroperoxide, 2-[bis(2-chloroethyl)amino]tetrahydro-2-oxido-2H-1,3,2-oxazaphosphorin-4-yl

Descrição

4-Hydroperoxycyclophosphamide (4-HPPC) is a cytotoxic agent with anti-cancer properties. It is a prodrug that is converted to 4-hydroxycyclophosphamide, the active form of the drug, by hydrolases in cells. The cytotoxicity of 4-HPPC has been demonstrated using a model system of human erythrocytes and HL60 cells. This drug also has an effect on tumor growth and metastasis, as well as on bowel disease. Rats treated with 4-HPPC showed decreased levels of blood glucose, increased glutathione peroxidase activity, and a decrease in the number of colonic tumors after only one dose. The low-dose group had improved mitochondrial membrane potential and an increase in cell factor receptor activity. These results indicate that 4-HPPC may be a useful anti-cancer compound for treating various types of cancer including colon cancer.

• Marca: Biosynth

Propriedades químicas

• Peso molecular: 293.08 g/mol
• Fórmula: C₇H₁₅Cl₂N₂O₄P
• Pureza: Min. 95%
• Cor/forma: Powder
• InChI: InChI=1S/C7H15Cl2N2O4P/c8-2-4-11(5-3-9)16(13)10-7(15-12)1-6-14-16/h7,12H,1-6H2,(H,10,13)
• Chave InChI: InChIKey=VPAWVRUHMJVRHU-UHFFFAOYSA-N
• SMILES: O=P1(N(CCCl)CCCl)NC(OO)CCO1