7-(2-Hydroxypropyl)guanine

CAS: 56247-84-8

Ref. 3D-FH24490

Informação sobre produto

• Nome: 7-(2-Hydroxypropyl)guanine
• Sinónimos: 2-Amino-1,7-dihydro-7-(2-hydroxypropyl)-6H-purin-6-oneN7-(2-Hydroxypropyl)guanine, 2-Amino-1,7-dihydro-7-(2-hydroxypropyl)-6H-purin-6-one, 2-Amino-7-(2-hydroxypropyl)-6,7-dihydro-1H-purin-6-one, 6H-Purin-6-one, 2-amino-1,7-dihydro-7-(2-hydroxypropyl)-, 7-(2-Hydroxypropyl)Guanine, N⁷-(2-Hydroxypropyl)guanine, N7-(2-Hydroxypropyl)guanine

Descrição

7-(2-Hydroxypropyl)guanine (7-HPG) is a nucleoside analogue that is used for the treatment of liver cancer. It is an alkylating agent, which reacts with cellular DNA to form crosslinks and inhibits DNA synthesis. 7-HPG is given intravenously and targets liver cells, as well as other tissues such as the pancreas and lung. The short-term exposure of 7-HPG in animals has not been found to cause any carcinogenic effects. This drug also has a neutral pH, making it suitable for use in patients who have difficulty tolerating acidic drugs. The repair mechanism of 7-HPG may be due to the cell type specificity or short duration of exposure.

• Marca: Biosynth

Propriedades químicas

• Peso molecular: 209.21 g/mol
• Fórmula: C₈H₁₁N₅O₂
• Pureza: Min. 95%
• InChI: InChI=1S/C8H11N5O2/c1-4(14)2-13-3-10-6-5(13)7(15)12-8(9)11-6/h3-4,14H,2H2,1H3,(H3,9,11,12,15)
• Chave InChI: InChIKey=JVWVMKYNORDKGP-UHFFFAOYSA-N
• SMILES: CC(O)Cn1cnc2nc(N)[nH]c(=O)c21