1H-Indazol-3-ylamine
CAS: 874-05-5
Ref. 3D-FI16217
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Informação sobre produto
- 1H-Indazol-3-Ylamine
- 1H-Indazole, 3-amino-
- 1H-Indazole,3-amino- (6CI,7CI,8CI)
- 3-Amino-1H-indazole
- 3-Aminoindazole
- 3-Indazolamine
- Nsc 348887
- Nsc 44677
1H-Indazol-3-ylamine is a novel drug that has been shown to inhibit the Abl kinase. The drug binds to the ATP binding site at the N-terminus of the kinase and prevents ATP from activating the kinase. It also inhibits the phosphorylation of Bcr-Abl, which is essential for its growth and survival. 1H-Indazol-3-ylamine has been shown to be active against cells with a high level of bcr-abl kinase activity, such as K562 leukemia cells, in transfection experiments. This drug also inhibits Bcr-Abl tyrosine phosphorylation and blocks signals downstream of Bcr-Abl, such as protein synthesis and cell division.
1H-Indazol-3-ylamine has been found to have potential anticancer activity against atherosclerotic cardiovascular disease (CVD) in mice models by inhibiting lipid accumulation in
Propriedades químicas
Consulta técnica sobre: 3D-FI16217 1H-Indazol-3-ylamine
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