2-(Isopropylsulphonyl)aniline
CAS: 76697-50-2
Ref. 3D-FI75046
| 1g | Descontinuado | ||
| 2g | Descontinuado | ||
| 5g | Descontinuado | ||
| 10g | Descontinuado | ||
| 25g | Descontinuado |
Informação sobre produto
Nome:
2-(Isopropylsulphonyl)aniline
Sinónimos:
- 1-Amino-2-(isopropylsulfonyl)benzene
- 2-Isopropylsulfonylaniline
- 1-Amino-2-(isopropylsulphonyl) benzene
- 2-(Isopropylsulfonyl)Aniline
- 2-(Propane-2-Sulfonyl)-Phenylamine
- 2-(Isopropylsulfonyl)Benzenamine
Descrição:
2-(Isopropylsulphonyl)aniline (2-ISA) is a potent and selective inhibitor of the mitotic checkpoint kinase Mad2, which is implicated in cancer. 2-ISA has been shown to inhibit the mitotic spindle assembly checkpoint by binding to Mad2 and inhibiting its ability to phosphorylate Mad1 and Cdc20. In vitro experiments have demonstrated that 2-ISA blocks cell cycle progression in ht-29 cells, a colon cancer cell line, by preventing their entry into mitosis. 2-ISA has been shown to be an effective inhibitor of tumor growth in vivo. This agent also inhibits sorafenib, a drug that targets the Raf/MEK/ERK signaling pathway and is used for the treatment of cancer. The analogs of 2-ISA are being developed as potential anticancer agents.
Aviso:
Os nossos productos estão destinados exclusivamente para uso em laboratório. Para qualquer outra aplicação, por favor entre em contacto.
Marca:
Biosynth
Armazenamento a longo prazo:
Notas:
Propriedades químicas
Peso molecular:
199.27 g/mol
Fórmula:
C9H13NO2S
Pureza:
Min. 95%
InChI:
InChI=1S/C9H13NO2S/c1-7(2)13(11,12)9-6-4-3-5-8(9)10/h3-7H,10H2,1-2H3
Chave InChI:
InChIKey=GMLAMRMKROYXNZ-UHFFFAOYSA-N
SMILES:
CC(C)S(=O)(=O)c1ccccc1N
MDL:
Ponto de fusão:
Ponto de ebulição:
Ponto de inflamação:
Densidade:
Concentração:
EINECS:
Merck:
Código HS:
