6-Keto 17b-estradiol
CAS: 571-92-6
Ref. 3D-FK24761
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Informação sobre produto
- (17b)-3,17-Dihydroxyestra-1,3,5(10)-trien-6-one3,17b-Dihydroxyestra-1,3,5(10)-trien-6-one1,3,5(10)-Estratrien-3,17b-diol-6-one
- 6-Ketoestradiol
- (17Beta)-3,17-Dihydroxyestra-1,3,5(10)-Trien-6-One
- 3,17-Dihydroxyestra-1,3,5(10)-Trien-6-One
6-Keto 17b-estradiol is a metabolite of 17β-estradiol. It is used as a model system to study the biological properties of 17β-estradiol and the role of the hydroxyl group in its metabolism. 6-Keto 17b-estradiol is produced in rat liver microsomes by cytochrome P450, which converts estrone into 6-keto estrone. The biological properties of 6-keto 17b-estradiol have been studied in women with breast cancer. This metabolite shows anti-proliferative activity by binding to estrogen receptors and inhibiting protein synthesis. Its chemical stability can be improved by adding a disulfide bond. The contraceptive effect of 6-keto 17b-estradiol has been shown in studies on rats, where it was found to be effective in preventing pregnancy when given at high doses over an extended period of time.
Propriedades químicas
Consulta técnica sobre: 3D-FK24761 6-Keto 17b-estradiol
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