Informação sobre produto
Ast2818 mesylate is a small-molecule, orally active, selective factor receptor tyrosine kinase inhibitor that targets the epidermal growth factor receptor (EGFR) and its downstream signaling proteins. Ast2818 mesylate binds to the EGFR at a site distinct from the ATP binding site and prevents phosphorylation by protein tyrosine kinases. It inhibits cell proliferation by blocking the activation of downstream signaling proteins such as Ras, Raf, and Akt. The compound has been evaluated in preclinical studies for potential use as an antineoplastic agent in lung cancer. In these studies, Ast2818 mesylate inhibited tumor growth in mouse models of lung cancer. Further analysis showed that this effect was due to inhibition of epidermal growth factor receptor-mediated signaling pathways involved in cell proliferation and tumorigenesis.
Propriedades químicas
Consulta técnica sobre: 3D-FKD95855 Ast2818 mesylate
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