3-Methyl-2,3-dihydroindole hydrochloride
CAS: 4375-15-9
Ref. 3D-FM155467
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Informação sobre produto
- 1H-Indole, 2,3-dihydro-3-methyl-
- 2,3-Dihydro-3-methyl-1H-indole
- 2,3-Dihydro-3-methylindole
- 3-Methyl Indoline
- 3-Methyl-2,3-Dihydroindole
- 3-Methylindoline
- 3-methyl-2,3-dihydroindole-HCl
- Indoline, 3-methyl-
- 3-Methyl-2,3-dihydro-1H-indole
3-Methyl-2,3-dihydroindole hydrochloride is an ezh2 inhibitor. It is a chiral molecule that binds to the catalytic subunit of the enzyme histone H3 methyltransferase (EHMT1) and inhibits the transfer of methyl groups from S-adenosylmethionine to lysine residues in the DNA. The synthesis of this compound was achieved by a chemoenzymatic approach with a lipase as catalyst. This reaction system has been shown to be functional for the synthesis of molecules with different functional groups. 3-Methyl-2,3-dihydroindole hydrochloride has been reported to inhibit EHMT1 in living cells, which may lead to epigenetic changes in gene expression. The reaction time for this synthesis is about 30 minutes.
Propriedades químicas
Consulta técnica sobre: 3D-FM155467 3-Methyl-2,3-dihydroindole hydrochloride
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