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4-Methyl-7H-pyrrolo[2,3-d]pyrimidine
CAS: 945950-37-8
Ref. 3D-FM158215
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Informação sobre produto
4-Methyl-7H-pyrrolo[2,3-d]pyrimidine is an anti-HIV drug that has been shown to have a potent anti-HCV activity in molecular modeling studies. The compound has been optimized for binding to the HCV NS5B RNA polymerase and the lead discovery step has been completed. 4-Methyl-7H-pyrrolo[2,3-d]pyrimidine is a ligand that binds to the C2' hydroxyl group of the nucleoside analogs and prevents them from being incorporated into the growing DNA chain. This leads to a halt in viral replication. The conformation of this molecule was determined by molecular modeling techniques and its amino group was bioisosterically replaced by a carbocyclic nucleoside.
Propriedades químicas
Consulta técnica sobre: 3D-FM158215 4-Methyl-7H-pyrrolo[2,3-d]pyrimidine
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