Informação sobre produto
- (R)-(-)-[4-N,N-Dimethylamino]dinaphtho[2.1-d:1'.2'-f][1.3.2]dioxaphosphepine
- (R)-monophos
- (R)-(-)-(3,5-Dioxa-4-phospha-cyclohepta[2,1-a3,4-a']dinaphthalen-4-yl)dimethylamine
- (R)-(-)-4-(N,N-Dimethylamino)-dinaphtho[2,1-d:1',2'-f]-1,3,2-dioxaphosphepin
(R)-Monophos is an antitumor agent that inhibits the growth of cancer cells. It is a potent inhibitor of DNA synthesis, which is essential for cell division. (R)-Monophos has been shown to be effective against a number of cancer cell lines, including leukemia, lymphoma and breast cancer cells. This drug is synthesized by the cross-coupling reaction between a phosphine and an activated carbonyl group. The mechanism of this reaction involves the formation of an iminium ion intermediate with phosphite as the leaving group. The iminium ion reacts with a chloroformate to produce (R)-monophos and hydrogen chloride as byproducts. Crystal x-ray diffraction data have provided evidence for this mechanism.
Propriedades químicas
Consulta técnica sobre: 3D-FM180381 (R)-Monophos
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