Methyl 6-chloronicotinate
CAS: 73781-91-6
Ref. 3D-FM36752
25g | 136,00 € | ||
50g | 168,00 € | ||
100g | 239,00 € | ||
250g | 470,00 € | ||
500g | 723,00 € |
Informação sobre produto
- 6-Chloronicotinic acid methyl ester
- Methyl 6-chloropyridine-3-carboxylate
- 3-Pyridinecarboxylic acid, 6-chloro-, methyl ester
Methyl 6-chloronicotinate is a quinoline derivative that has been shown to have cytotoxic effects. This compound inhibits the DNA repair protein O6-alkylguanine-DNA alkyltransferase (O6-AGAT) and induces apoptosis by binding to the cation channel and inhibiting the influx of calcium ions, which leads to an increase in intracellular calcium levels. Methyl 6-chloronicotinate also inhibits cancer cell proliferation through its interaction with the voltage-gated sodium channels and potassium channels, which leads to cell death. The molecular modeling study revealed that methyl 6-chloronicotinate binds to a deep hydrophobic pocket on the surface of hct116 cells, indicating that this drug may be a potential anticancer agent.
Propriedades químicas
Consulta técnica sobre: 3D-FM36752 Methyl 6-chloronicotinate
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