
Pyrazine-2-carboxylic acid
CAS:
Ref. 3D-FP15650

Informação sobre produto
Pyrazine-2-carboxylic acid is a potent inhibitor of bacterial x-lactamase. It was found that the inhibition of x-lactamase by pyrazine-2-carboxylic acid could be attributed to hydrogen bonding interactions with the active site of the enzyme and a high rate constant for the reaction. The antibacterial efficacy of pyrazine-2-carboxylic acid against wild type Streptococcus pneumoniae and methicillin resistant Staphylococcus aureus (MRSA) was tested and found to be comparable to that of benzylpenicillin. Pyrazine-2-carboxylic acid also has biological properties, such as an inhibitory effect on protein synthesis in bacteria, which may be due to its ability to bind to ribosomes.
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