Informação sobre produto
Pegloticase is a PEGylated urate oxidase enzyme used to treat chronic granulomatous disease. It is also a methyltransferase inhibitor that prevents the activation of bacterial enzymes, such as cytosine-guanine dinucleotide phosphate (CpG) methyltransferase. This enzyme catalyses the methylation of CpG sites on DNA, which are important for maintaining normal gene expression. Pegloticase has been shown to be effective in reducing the activity of inflammatory bowel disease and rheumatoid arthritis. It also has been shown to have pharmacological effects on congestive heart failure, hypersensitivity syndrome, and bowel diseases due to its anti-inflammatory properties. Pegloticase has not been studied in patients with hepatic impairment or taking nonsteroidal anti-inflammatory drugs.
