Quinine hydrochloride dihydrate

CAS: 6119-47-7

Ref. 3D-FQ43018

Informação sobre produto

• Nome: Quinine hydrochloride dihydrate
• Sinónimos: (4beta,8alpha,9R)-6'-methoxycinchonan-9-ol hydrochloride dihydrate, (9R)-6'-methoxycinchonan-1'-ium-9-ol chloride dihydrate, (R)(6-Methoxy-4-quinolyl)(5-vinyl-1-azabicyclo[2.2.2]oct-2-yl)methanol hydrochloride, Cinchonan-9-ol, 6′-methoxy-, hydrochloride, hydrate (1:1:2), (8α,9R)-, Cinchonan-9-ol, 6′-methoxy-, monohydrochloride, dihydrate, (8α,9R)-, Quinine Hydrochloride Dihydrate

Descrição

Quinine hydrochloride dihydrate is a natural compound that has been used for centuries as a treatment for malaria. It is an effective anti-malarial agent and is also used to treat nocturnal leg cramps, although it has a low potency. Quinine hydrochloride dihydrate is active against the parasite Plasmodium falciparum in vitro. It binds to hemozoin, which is the pigment that the malaria parasites produce during digestion of hemoglobin from red blood cells. This binding inhibits the growth of the parasite and causes cell death by inhibiting protein synthesis. Quinine hydrochloride dihydrate has been shown to be genotoxic in vivo, but not in vitro. The genotoxic effects may be due to its ability to create reactive oxygen species (ROS) through photochemical reactions with light exposure and other chemical reactions, such as thermal expansion or matrix effects.

• Marca: Biosynth

Propriedades químicas

• Peso molecular: 396.91 g/mol
• Fórmula: C₂₀H₂₄N₂O₂·HCl·2H₂O
• Cor/forma: Powder