JZP 361

CAS: 1680193-80-9

Ref. 3D-FSC19380

Informação sobre produto

• Nome: JZP 361
• Sinónimos: Methanone, [4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinyl]-1H-1,2,4-triazol-1-yl-, [4-(8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinyl]-1H-1,2,4-triazol-1-ylmethanone

Descrição

JZP 361 is a peptide fragment of the human protein, thrombospondin-1. It is a potent inhibitor of TGF-β1 and IL-1β signaling, which are both implicated in inflammatory responses. JZP 361 has been shown to inhibit IL-6 production by macrophages and to activate neutrophils by increasing the expression of CD11b and CD18 proteins. These effects may be mediated through interactions with TGF-β receptors, IL-1 receptors, or integrins. The antibody against JZP 361 has been shown to bind specifically to the peptide fragment at pH 7.4 in a range of 1-500 nM concentration.

• Marca: Biosynth

Propriedades químicas

• Peso molecular: 405.9 g/mol
• Fórmula: C₂₂H₂₀ClN₅O
• Pureza: Min. 95%