4-thien-3-ylbenzoic acid
CAS: 29886-64-4
Ref. 3D-FT59073
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Informação sobre produto
- 4-(Thien-3-yl)benzoic acid
- 4-(Thiophen-3-Yl)Benzoic Acid
- Benzoic acid, 4-(3-thienyl)-
- Benzoic acid, p-3-thienyl-
4-Thienylbenzoic acid is a reactive compound that binds covalently to the active site of phosphodiesterase type-5 (PDE5) and blocks the hydrolysis of cyclic nucleotides. This leads to an accumulation of cyclic monophosphate, which can lead to alopecia areata. 4-Thienylbenzoic acid has also been shown to induce laser ablation in mice with alopecia areata. The drug has a high affinity for female sex hormone receptors and is transported by drug transporters such as P-glycoprotein. The drug's concentration-time curve is linear and it has a half-life of 2 hours when administered orally at physiological levels. The logistic regression model showed that the body mass index was significantly correlated with 4-thienylbenzoic acid concentrations.
Propriedades químicas
Consulta técnica sobre: 3D-FT59073 4-thien-3-ylbenzoic acid
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