(R1)-(Tetrahydrofuran-2-yl)-5-fluorouracil
CAS: 37076-68-9
Ref. 3D-FT76523
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Informação sobre produto
- Tegafur
- 2,4(1H,3H)-Pyrimidinedione, 5-fluoro-1-(tetrahydro-2-furanyl)-, (R)-
- 2,4(1H,3H)-Pyrimidinedione, 5-fluoro-1-[(2R)-tetrahydro-2-furanyl]-
- 5-Fluoro-1-[(2R)-tetrahydro-2-furanyl]-2,4(1H,3H)-pyrimidinedione
- NSC 200695
- R-1-(Tetrahydrofuran-2-yl)-5-fluorouracil
- Uracil, 5-fluoro-1-(tetrahydro-2-furyl)-, (R)-
(R1)-(Tetrahydrofuran-2-yl)-5-fluorouracil is a prodrug of 5-FU, which is a chemotherapeutic drug used to treat colorectal adenocarcinoma. It is converted in the body to 5-FU by esterases and glucuronidases, which inhibits DNA synthesis and cell division. (R1)-(Tetrahydrofuran-2-yl)-5-fluorouracil has been shown to have anticancer activity in treatment trials with multivariate logistic regression analysis and enzyme activities. The conversion of (R1)-(Tetrahydrofuran-2-yl)-5-fluorouracil into 5-FU can be inhibited by using P450 inhibitors such as ketoconazole and erythromycin, suggesting that this pharmacological agent may not be suitable for patients with liver or renal impairment.
Propriedades químicas
Consulta técnica sobre: 3D-FT76523 (R1)-(Tetrahydrofuran-2-yl)-5-fluorouracil
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