3-(Trifluoromethyl)benzamide
CAS: 1801-10-1
Ref. 3D-FT78782
| 1g | A consultar | ||
| 5g | A consultar | ||
| 500mg | A consultar |
Informação sobre produto
- Benzamide, 3-(trifluoromethyl)-
- alpha,alpha,alpha-Trifluoro-m-toluamide
- m-Toluamide, α,α,α-trifluoro-
- m-Trifluoromethylbenzamide
- α,α,α-Trifluoro-m-toluamide
3-(Trifluoromethyl)benzamide is an acyl halide that is a potent, selective, and orally bioavailable b-raf inhibitor. 3-(Trifluoromethyl)benzamide has been shown to inhibit the growth of colon cancer cells in vitro and in vivo. This compound also has the ability to cross the blood-brain barrier, which may be due to its high lipophilicity and low molecular weight. 3-(Trifluoromethyl)benzamide inhibits b-raf phosphorylation by blocking the cb2 receptor agonist binding site on b-raf. This inhibition results in decreased levels of c-jun N-terminal kinase (JNK), which leads to apoptosis. The pharmacophore for this drug includes a hydrophobic region that binds to the ATP binding site of b-raf and a carboxylic acid moiety that binds to the serine/threonine
Propriedades químicas
Consulta técnica sobre: 3D-FT78782 3-(Trifluoromethyl)benzamide
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