Trans-4-hydroxy-lomustine
CAS: 56239-24-8
Ref. 3D-GCA23924
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Informação sobre produto
Trans-4-hydroxy-lomustine is a pyridinium salt of the anti-cancer drug lomustine, which is used to treat various types of cancers. It is administered orally and has been shown to have antitumour activity in animal studies. Trans-4-hydroxy-lomustine is metabolized by cytochrome P450 enzymes, including CYP2C8, CYP2C9, and CYP3A4. The major metabolites are monohydroxylated trans-4-hydroxy lomustine, which inhibits DNA synthesis and protein synthesis in cells. This drug also has stereoselective effects on tumor cells compared to normal tissue cells. Trans-4-hydroxy lomustine has high lipophilicity due to its quaternary ammonium group.
Propriedades químicas
Consulta técnica sobre: 3D-GCA23924 Trans-4-hydroxy-lomustine
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